Neuried, Germany, and Copenhagen, Denmark, 17 January 2024 – AMSilk, a global leader in advanced materials made from spider silk-based proteins, and 21st.BIO, a leader in bioproduction, today announced that they have joined forces to accelerate the upscaling of AMSilk’s silk protein production to unprecedented levels. As part of the partnership, 21st.BIO has developed a new protein production strain created from highly specialized precision fermented microorganisms, ensuring that AMSilk can meet demand as it increases production from the laboratory to industrial scale.

The new strain ensures extracellular expression of silk proteins, enabling manufacturing at unprecedented productivity levels due to higher yield and greater efficiency, thereby reducing production costs.

Due to its unique combination of strength and flexibility, spider silk is the gold standard of bio industrial materials. AMSilk’s spider silk-based proteins are wholly biodegradable and biocompatible. Based on a renewable plant based feedstock, AMSilk fibers do not contain any substances of animal origin and come with a CO2 greenhouse gas emission reduction of up to 90% and more than 90% less land and water use compared to other protein fibers. Their high-performance qualities enable a wide range of applications in the textile, homecare, biomedical, and automobile industries.

The AMSilk x 21st.BIO genesis

As one of the world’s first industrial scale suppliers of advanced materials made from spider silk-based proteins, AMSilk has been redefining the performance fiber category since 2015, with applications in footwear and garments, and even interior components for automobiles. With a strong patent portfolio, AMSilk is leading the discovery of performance materials based on spider silk proteins.

21st.BIO benefits from the most advanced precision fermentation technology platform in the industry, with production strains that have been perfected for over 40 years and used in dozens of products on the market today. Working in close collaboration with AMSilk, 21st.BIO’s scientists have developed and optimized new production strains, fermentation and downstream processes to support upscaled production and significantly reduce unit costs. This will enable AMSilk to further broaden its portfolio into different types of fibers and proteins, with applications in the broader mid-market.

Gudrun Vogtentanz, Chief Scientific Officer, AMSilk said: “AMSilk’s protein-based products unlock the secrets of spider silk to create engineerable structures and solutions. Through 21st.BIO, we now have access to more efficient production strains, which are a game changer in terms of the efficiency and sustainability of our feedstock. Moving production quantities from kilos to tons brings AMSilk’s technology to the next level. This collaboration with 21st.BIO is key to accelerating time-to-market for AMSilk in the current scale-up phase.”

Ulrich Scherbel, Chief Executive Officer, AMSilk commented: “By partnering with 21st.BIO, we are succeeding where so many have struggled, delivering high performance precision fermentation at the right quality and cost parameters, and at a true industrial scale.” 2

Thomas Schmidt, Chief Executive Officer, 21st.BIO added: “We founded 21st.BIO to help companies cross over from interesting innovations at lab scale to reliable industrial biotech production in a timely and risk mitigated way. With spider silk proteins this has been challenging, but AMSilk is the first to be able to achieve that goal and bring spider silk proteins into large scale production. The world needs innovators and category shapers like AMSilk and our job is to help them succeed.”

Per Falholt, Chief Scientific Officer, 21st.BIO continued: “We are incredibly proud to support companies like AMSilk. Our partnership has already led to some key milestone achievements, such as the world’s first extracellular expression of spider silk protein, which facilitates processes and enables manufacturing at unprecedented productivity levels. We are confident that within a short time frame, we can achieve a significant reduction in production costs, enabling AMSilk to enter higher value markets.”

The potential for spider silk proteins produced using precision fermentation

Global bioplastics production will more than triple until 2026, from around 2.4 million tons in 2021 to 7.5 million tons in 2026[1]. There is a rapidly growing need to adopt more environmental-friendly materials. AMSilk is helping to meet this need by using its outstanding proprietary technology platform for large volume proteins, designing and customizing material properties at a molecular level depending on the final application or properties required.

AMSilk has developed a wide range of use cases for its silk proteins, from developing the leading spinning process for silk protein fibers, to transforming proteins into silk beads, gels and solutions to unlock the power of their coating effects. AMSilk’s silk protein-based fibers set completely new standards within the apparel industry, offering unbelievably broad performance characteristics, ranging from ultra fineness to extreme strength, making them ideal as premium, low carbon material alternatives. AMSilk has also entered the performance yarn segment with technical yarns for the automotive industry – reflected in its collaboration with Mercedes Benz. AMSilk’s silk protein formulations bring exceptional filming properties to dishwashing and laundry care, providing outstanding performance benefits as a bioshield.

[1] Source: World Biopolymers and Bioplastics Innovation Forum | 1st – 2nd March 2023 | Leadvent Group (leadventgrp.com)

For more information, please contact:

21st.BIO

Mathilde Pinon, Marketing & Business Development Manager

m.pinon@21st.BIO

AMSilk GmbH

Isabel Rosenberger, Senior Manager Marketing & Communications

Tel. +49 (0) 151 6106 3269

E-Mail: isabel.rosenberger@amsilk.com

Optimum Strategic Communications

Nick Bastin, Vici Rabbetts, Katie Flint

Tel: +44 (2)03 922 1906

E-mail: amsilk@optimumcomms.com

About AMSilk

AMSilk is a global leader in advanced materials made from spider silk-based proteins. AMSilk’s spider silk-based proteins are wholly biodegradable and biocompatible. Based on a vegan raw material, they do not contain any substances of animal origin and come with 8x lower CO2 emissions and more than 90% less land and water use than traditional materials. Their high-performance qualities enable a wide range of applications in the textile, homecare, biomedical, and automobile industries.

AMSilk’s truly sustainable materials outperform existing, fossil-based products not only through their optimal relationship between performance and positive environmental impact, but also through the adaptability of multiple benefits to a broad range of meaningful applications. AMSilk aims to expand the use of its biobased, biodegradable, recyclable, and biocompatible products, reducing dependence on the natural resources of the planet. The Company has already collaborated with industry-leading global companies and plans to continue partnering with influential worldwide enterprises in its vision to make high performance materials for a sustainable future.

About 21st.BIO

Founded in 2020, 21st.BIO is headquartered in Copenhagen, Denmark, with a strong scientific and commercial presence in Davis, California. On a mission to support bioindustrial companies globally in upscaling from molecule innovation to large-scale production, 21st.BIO enables its customers to meet market demands, and thereby advance the green transition globally. 21st.BIO focuses on developing industrial production technology for proteins and other molecules of interest for food, materials, and agricultural industries. Established as a fully integrated end-to-end partner, 21st.BIO supports its customers from technical assessment, strain development and optimization, production processes and upscaling, tech transfer to large scale manufacturing and regulatory services.